Based on HRMRI to research the effect of resolving phlegm and activating blood circulation to dredge collaterals on plaque stability and cerebral perfusion in sICAS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800017178

Enrollment

Unknown

Registered

2018-07-17

Start date

2018-08-01

Completion date

Unknown

Last updated

2018-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

symptomatic intracranial atherosclerotic stenosis, sICAS

Interventions

control group:Control the risk factors, Aspirin 100mg po qd 180days, clopidogrel 75mg po qd 90days

experimental group:Control the risk factors, Aspirin 100mg po qd 180days, clopidogrel 75mg po qd 90days, HTHXTLF po bid 180days

Eligibility

Sex/Gender

All

Age

40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Compliance with the diagnostic criteria of sICAS in Western Medicine; 2. Compliance with the diagnostic criteria of apoplexy in Chinese Medicine; 3. Compliance with the diagnostic criteria of syndrome factors of apoplexy(Qi deficiency=10point and Stasis of blood=10point and Phlegm dampness =10point); 4. The NIHSS score of the patient was 3-22 points before the treatment; 5. HRMRI detected intracranial atherosclerotic plaques and low perfusion state,the degree of stenosis is more than 50%; 6. Dynamic electrocardiogram showed no myocardial damage; 7. Ischemic stroke and TIA are related to intracranial artery stenosis; 8. First onset or history of ischemic stroke, but no serious sequelae remain; 9. Between 40 and 80 years of age; 10. Able to sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Acute ischemic stroke in the last three weeks; 2. Cerebral embolism and intracranial hemorrhage or hemorrhagic cerebral infarction within 6 weeks; 3. Patients also suffers from intracranial aneurysms, vascular malformations, or brain tumors; 4. Heart, liver, kidney and other important organ failure and mental patients; 5. Patients with stroke caused by non atherosclerotic vascular stenosis, includes vasculitis, vasospasm, moyamoya disease, etc; 6. Hemoglobin is lower than 100g/L,Platelet count is less than 100 x 109/L,INR is more than 1.5(irreversible),bleeding factor can not be corrected; 7. Patients with severe cerebral hypofunction.

Design outcomes

Primary

Measure	Time frame
HRMRI;NIHSS;SS-QOL;Clinical efficacy evaluation of Chinese medicine for apoplexy;Symptom scale of traditional Chinese Medicine;	—

Secondary

Measure	Time frame
TESS;Coagulation function;liver function;renal function;Routine blood test;	—

Countries

China

Contacts

Public ContactRongjuan Guo

Dongfang Hospital of Beijing University of Chinese Medicine

dfguorongjuan@163.com+86 18611377633

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026