postoperative nausea and vomiting
Conditions
Interventions
dexmedetomidine (Dex) group:Patient-controlled intravenous analgesia is established with 100 ml of 0.5 mg/ml morphine plus 1 µg/ml dexmedetomidine.
control (Ctrl) group:Patient-controlled intravenous analgesia is established with 100 ml of 0.5 mg/ml morphine
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Adult female patients aged between 18 and 65 years old; (2) Scheduled to undergo elective gynaecological laparoscopic surgery (myomectomy,hysterectomy and radical resection of endometrial carcinoma); (3) Preoperative American Society of Anaesthesiologists physical status I~II.
Exclusion criteria
Exclusion criteria: (1) Refuse to participate in the trial; (2) History of schizophrenia, epilepsia, Parkinson's Disease or myasthenia gravis; (3) Unable to communicate due to coma, severe dementia or language barrier; (4) Obesity (BMI>30kg/m 2); (5) Preoperative LVEF<30%, sick sinus syndrom, severe sinus bradycardia(heart rate<50bpm) or atrioventricular block at least II without pacemaker; (6) Preoperative severe hepatic disease (Child-pugh grade C or above); (7) Preoperative chronic renal failure (need dialysis); (8) Use of antiemetics , psychotropic drugs, opioids, antihistamine or glucocorticoids within 24 h before surgery; (9) Preoperative radiochemotherapy; (10) Pregnancy or breastfeeding or plan to be pregnancy; (11) Other reasons not suitable for participating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting;PONV intensity scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;PCIA use and additional dose of analgesic; | — |
Countries
China
Contacts
Public ContactGeng Zhiyu
Peking University First Hospital
Outcome results
None listed