Kidney cancer
Conditions
Interventions
Gold Standard:Enhanced CT or PDG-PET/CT
Index test:PSMA-PET/CT
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The subject has clinical diagnosed of locally advanced/metastatic renal cancer, which conforms to any of the following: (1) T3-t4 stage tumor (tumor diameter greater than 10cm, accompanied by tumor thrombus and/or extraperitoneal invasion); (2) Preoperative imaging of renal hilum and/or retroperitoneal lymph node enlargement; (3) Accompanied by distant metastasis; 2. Primary renal cancer can be surgically removed; 3. The life expectancy is more than or equal to 3 months; 4. The subject is more than or equal to 18 years old; 5. The subject has 0-2 points according to ECOG; 6. Functions of major organs: No significant abnormalities are found in liver, kidney, bone marrow, heart and other important organs; 7. No significant abnormalities are found on ECG, or the abnormalities show no clinical significance; 8. Women of childbearing age must confirm non-pregnancy prior to enrollment. All enrolled subjects (male and female) must take adequate barrier methods for birth control during the entire treatment period and within 4 weeks after the end of treatment; 9. The subject must be capable of understanding and voluntarily signing the informed consent. The informed consent must be signed prior to any tests.
Exclusion criteria
Exclusion criteria: 1. Unable to perform primary nephrectomy and regional lymph node dissection; 2. The subject has received systematic treatment for metastatic renal cancer : targeted drug/immune/cytokine therapy; 3. Severe heart and cerebral vascular diseases, uncontrollable hypertension and diabetes, and incomplete renal function or renal failure; 4. HIV positive, or other immune deficiencies; 5. Clear history of metal illness, affecting his/her understanding of informed consent and compliance with study; 6. Other malignant tumors which have not been cured; 7. Women in pregnancy or lactation; 8. Any condition that is not stable or may jeopardize the safety of the subject and his/her compliance with the study; or other factors that the investigators believe that the subject is not suitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| predictive value;Sensibility;Specificity;Veracity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postive predictive value;Negative predictive value;positive likelihood ratio;negative liklihood ratio;odds ratio;omission diagnostic rate;misdiagnosis rate; | — |
Countries
China
Contacts
Public ContactDong pei
Sun Yat-sen University Cancer Center
Outcome results
None listed