cervical intraepithelial neoplasia
Conditions
Interventions
Group 1:Bifidobacterium Lactobacillus M8
Group 2:placebo
Sponsors
Weihai Municipal Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. aged 20~50 years old; 2. HPV screening in 1 months before the operation was positive for high-risk type; 3. conforms to WHO diagnostic criteria for cervical intraepithelial neoplasia; 4. HPV follow-up data were obtained from vaginal microecology results without vaginitis related treatment within 1 months before operation; 5. abstinence during the follow-up period; 6. informed and voluntarily participated in the study and signed informed consent (approved and approved by the hospital ethics committee).
Exclusion criteria
Exclusion criteria: 1. pregnant or lactation patients; 2. female patients who did not use any contraceptive measures; 3. unstable life signs and unstable patients; 4. combined with neurological, mental disorders, active malignancies, stroke, myocardial infarction and other serious primary diseases; 5. there were gastrointestinal bleeding, irritable bowel syndrome, Crohn disease or ulcerative colitis, and gastrointestinal tract history; 6. patients who took antibiotics, corticosteroids or other immunosuppressive agents, including probiotics, prebiotics, food and drugs in the past 1 months; 7. allergic reaction to the sample or obvious gastrointestinal symptoms such as intolerance; 8. patients received other clinical trials at the same time; 9. researchers who were identified by the researchers could not finish the research in time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vagina Microecology; | — |
Countries
China
Contacts
Public ContactZhang Shihong
Weihai Municipal Hospital
Outcome results
None listed