Nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:IMRT alone
Contrast group:Concurrent chemoradiotherapy with cisplatin
Sponsors
Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Histologic diagnosis of non-keratinizing nasopharyngeal carcinoma(according to the pathological classification of WHO); 2. Tumor staged as T1-2N1/T2-3N0(according to the 8th AJCC edition)(appendix I); 3. No evidence of distant metastasis(M0); 4. Functional state:KPS>=70(appendix II); 5. Normal bone marrow function:leucocyte count > 4 * 10^9/L, hemoglobin of male > 110g/L and hemoglobin of female > 110g/L, platelet count > 100 * 10^9/L; 6. Normal liver function:ALT and AST 60 ml/min; 8. All patients must be informed of the investegational nature of this study and signed the written informed consent.
Exclusion criteria
Exclusion criteria: 1. The lymph node capsule of cervical lymph node was invaded, the maximum diameter of transverse section of cervical lymph nodes was greater than or equal to 3cm,and the positive lymph nodes were located in the IV region and / or Vb region; 2. The pathological type was keratinized squamous cell carcinoma or basosquamous cell carcinoma according to the pathological classification of WHO; 3. Aged > 70 or 1.5 * ULN),and mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progress-free survival;Toxicities; | — |
Secondary
| Measure | Time frame |
|---|---|
| Distant metastasis-free survival;Locoregional relapse-free survival;Overall Survival; | — |
Countries
China
Contacts
Public ContactWei Jiang
Affiliated Hospital of Guilin Medical University, Guilin, PR China
Outcome results
None listed