Parkinson‘s disease
Conditions
Interventions
Rehabilitation group (speech-language disorders):Anti-parkinson drugs plus LSVT
Control group (speech-language disorders):Anti-parkinson drugs
Rehabilitation group (gait disorders):Anti-parkinson drugs plus intensive exercise combined with VR therapy
Control group (gait disorders):Anti-parkinson drugs
Sponsors
Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 45 or older, male or female; 2. Diagnosed as idiopathic Parkinson's disease(Clinically Established PD or Clinically Probable PD) with speech-language disorders or gait disorders according to the 2015 MDS Clinical Diagnostic Criteria for Parkinson's disease; 3. With the modified Hoehn & Yahr (H&Y) staging 2.5-5; 4. Each subject or his/her legal guardian agrees to participate in this study and signs the written informed consent for participation.
Exclusion criteria
Exclusion criteria: 1. Secondary Parkinsonismcaused by vascular factors, toxins and drugs et al., or Parkinsonism-plus Syndrome; 2. Disorders of consciousness, severe organic diseases, cerebral hemorrhage, cerebral ischemic stroke, severe heart and lung diseases, severe liver and kidney dysfunction, severe diabetes, severe hearing and visual impairment; 3. With a history of severe brain tumors or brain surgery; 4. According to the researchers'judgment, those who may not complete the study in accordance with the requirements of the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait speed;The time in "Timed up and go test";UPDRS II & III;LSVT-Loud Praat Analysis;Perceptual Rating Form (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| The modified Hoehn & Yahr scale (H&Y) ;39-item Parkinson's disease questionnaire (PDQ-39);Voice Handicap Index (VHI); | — |
Countries
China
Contacts
Public ContactQing Wang
Zhujiang Hospital of Southern Medical University
Outcome results
None listed