Inactive HBsAg Carriers
Conditions
Interventions
Treatment group:PEG-IFN135µg/W, HBsAg50IU/ml at 24 week, stop treatment
Control group:no treatment
Sponsors
Beijing You'an Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The diagnosis of inactive HBsAg carriers was consistent with the 2015 Chronic Hepatitis B Prevention Guide. HBsAg positive >2 years, HBsAg<200IU/ml,HBeAg negative, HBV DNA<20IU/ml. ALT level is normal. Ultrasound B or Fibroscan did not indicate cirrhosis.No antiviral treatment within one year.
Exclusion criteria
Exclusion criteria: (1) Patients with HAV, HCV, HDV, HEV infection and autoimmune liver disease; (2) Pregnancy and lactation women and patients who are preparing to give birth in the near future; (3) Severe liver dysfunction or decompensatory cirrhosis; (4) History of serious heart disease, including unstable or uncontrolled heart disease within six months; (5) history of mental illness; (6) uncontrollable epilepsy; (7) alcoholic or drug addict; (8) Uncontrolled diabetes, hypertension, thyroid diseases, retinopathy, autoimmune diseases, etc.; (9) Neutrophils51umol/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg; | — |
Countries
China
Contacts
Public ContactCao Zhenhuan
Beijing You'an Hospital, Capital Medical University
Outcome results
None listed