Pain during liver resection
Conditions
Interventions
Two groups:Use of qNOX index to guide the pain management using fentanyl during liver surgery versus Use of Shafer’s Pharmacokinetic model to guide the pain management using fentanyl during liver surg
Sponsors
Departmental resources
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective liver surgery; 2. ASA I to III; 3. Age between 18-80 years old.
Exclusion criteria
Exclusion criteria: 1. Laparoscopic surgery; 2. Concomitant non-hepatobiliary surgery; 3. Drug allergy to fentanyl/local anesthetic agents; 4. Anticipated operative duration less than 90 min; 5. Chronic pain patients; 6. Preoperative opioid consumption; 7. Patients with obstructive sleep apnea; 8. Psychiatric disorders; 9. Inability to use PCA device; 10. Severe Chronic Obstructive Airway Disease; 11. Perioperative massive bleeding with hemodynamic instability; 12. History of severe postoperative nausea and vomiting.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total dose of fentanyl administered intraoepratively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first analgesic demand at RR;Total dose of rescue fentanyl given at RR;Sedation score at RR;VAS for analgesia at rest and during cough, sedation, nausea and pruritus at RR and during the first 24 hours postoperatively;Total PCA fentanyl consumption within the first 24 hours postoperatively;No of patients requiring naloxone for opioid overdose;Total doses of naloxone given for opioid overdose;No of patients requiring antiemetic for PONV;Chronic pain assessment at 3-month postoperative interval; | — |
Countries
China
Contacts
Public ContactDr Wong Tak-Kin
Tuen Mun Hospital
Outcome results
None listed