acute pain after lumbar surgery
Conditions
Interventions
D1:0.2 mg/kg dexamethasone was injected intravenously 1 h before surgery, and 0.2 mg/kg saline was intravenously administered immediately after the surgery
D2:0.2 mg/kg saline was injected intravenously 1 h before surgery, and 0.2 mg/kg dexamethasonewas intravenously administered immediately after the surgery
C?:Intravenous injection of the same dose of normal saline at each time point
Sponsors
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. aged 18-75 years; 2. American Society of Anaesthesiologists (ASA) physical status classification of I-II; 3. Lower extremity radiation pain with or without numbness symptoms lasted for more than 3 months, regular conservative treatment for 8 weeks is invalid; 4. patients who are scheduled for one or two segmental posterior lumbar decompression and bone graft fusion.
Exclusion criteria
Exclusion criteria: 1. diabetic mellitus; 2. pregnancy or lactation; 3. previous lumbar spine surgery; 4. inability to cooperate; 5. had any known allergy or contraindication to dexamethasone; 6. undergone more than three levels of laminectomy; 7. had received chronic steroid or opioids; 8. severe hepatic or renal impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue pain scale on low back and leg; | — |
Secondary
| Measure | Time frame |
|---|---|
| CRP, IL-6, IL-10 and TNF-a;Oswestry disability index score;Lower limb numbness, fatigue and weakness;Improved Macnab efficacy assessment;Frequecy for compress PICA;the first pressing time of the analgesic pump;Frequecy for analgesic rescue and consumption;Length of hospital stay;Sleep quality;Adverse reaction such as nause and vomiting, postoperative sore throat, hoaseness; | — |
Countries
China
Contacts
Public ContactYanming
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed