Major Depressive Disorder
Conditions
Interventions
1:medication as usual
2:medication assisted DIT
3:medication assisted general supportive psychotherapy
Sponsors
Clinical Center of Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: To be eligible, participants need to be between the ages of 18-65 years; meet DSM-5 criteria for MDD based on the Mini International Neuropsychiatry Interview (ref), administered by psychiatrists with at least associate chief level, with a score =18 on the 17-item Hamilton Depression Rating Scale (HAMD-17); have completed at least primary school education (i.e., =6 years of education); be antidepressant drug na?ve or discontinued antidepressant medications at least 8 weeks prior to the screen visit; have not received psychotherapy in the last 6 months; provide written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria include a severe concurrent medical condition; significant visual and auditory deficits; lifetime history of psychosis or bipolar disorder; history of substance use disorders in the last 24 months,; history of psychotic features of affective disorder; high suicide risk; personality disorders; and intellectual disability. Other psychiatric comorbidities will be allowed so long as the MDD is the primary and predominant disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| response rate;remission rate; | — |
Countries
China
Contacts
Public ContactJianyin Qiu
Shanghai Mental Health Center
Outcome results
None listed