Non - small Cell Lung Cancer
Conditions
Interventions
Case series:Establishment of PDX models and mini-PDX susceptibility testing using tumor tissue and puncture samples
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Histopathological examination confirmed the diagnosis of NSCLC, and needs systematic anticancer therapy; 2. Clinical examination with no other tumor; 3. Can obtain fresh tumor tissues or pleural effusion or ascites samples by surgical resection or biopsy; 4. With tumor foci meeting the RECIST 1.1 standard; can evaluate the efficacy by CT/MRI; 5. KPS scores=60; expected survival = 3 months; 6. Voluntary to participate and sign informed consent document; Compliance is good, can actively treat and cooperate with follow-ups.
Exclusion criteria
Exclusion criteria: 1. Unplanned reoperation after surgery; 2. During the course of treatment, the patient was found to have other tumors, or a second tumor was found, which interfered with this experimental study; 3. KPS score = 60 points or blood biochemical tests suggest that patients are not suitable for continuing chemotherapy or chemotherapy has been delayed; 4. Cannot or refuse to collect tumor samples, including tumor tissue blocks, or malignant pleural effusion and ascites; 5. Refused to receive treatment plans or follow-up plans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;Progressive Free survival;Objective response rate; | — |
Countries
China
Contacts
Public ContactXiuyi Yu
he First Affiliated Hospital of Xiamen University
Outcome results
None listed