lymphoma
Conditions
Interventions
one:CHOP-L
two:BFM-90
Sponsors
Beijing Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with T cell NHL confirmed by histological morphology and immunohistochemistry included only 2 types: NK/T cell lymphoma and T lymphocytoma; 2. Circulating has at least one objectively measurable lesion; 3. Press aged 18 to 70 years male and female; 4. Superior primary care for patients; 5. ECOG 0 ~ ?, is expected to survive more than 3 month; 6. Pregnancy tests for women of child-bearing age must be negative; Men and women should agree to use effective contraceptives during treatment and within the following year; 7. Sign written informed consent form before screening test.
Exclusion criteria
Exclusion criteria: 1. Have central nervous system disease; 2. psychopath; 3. Other clinical studies are under way; 4. Severe infection; 5. Hepatic insufficiency, serum direct bilirubin, indirect bilirubin, transaminase were more than 2 times higher than normal.Serum total protein or albumin is lower than normal; 6. Renal insufficiency, creatinine clearance rate more than 2 times higher than normal, especially creatinine clearance rate less than 30ml/min. 7. Blood routine tests before admission: WBC < 3*10^9/L;Absolute number of neutrophils < 1.5*10^9/L; Platelet < 100*10^9/L (if bone marrow is not invaded); Absolute platelet count < 75*10^9/L (when bone marrow is invaded);Hb < 100 g/L; 8. Within 6 months prior to admission, the patient suffered from uncontrolled or severe cardiovascular diseases, including myocardial infarction, grade iii-iv heart failure, uncontrolled angina, etc.; 9. HIV antibody positive, HBsAg+ patients can be included in the group with hepatitis b DNA titer below 104 copies/ml after antiviral treatment; 10. Abnormal coagulation; 11. Women of childbearing age who were pregnant or lactating and were unwilling to use contraception during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR;CR;PR; | — |
Secondary
| Measure | Time frame |
|---|---|
| safety; | — |
Countries
China
Contacts
Public ContactJun Zhu
Beijing Cancer Hospital
Outcome results
None listed