Systemic inflammatory response syndrome
Conditions
Interventions
1:Tropisetron
Sponsors
Department of Anesthesiology, Beijing Chao-Yang Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Patients scheduled for elective off-pump coronary artery bypass grafting surgery; 18yr<Age<65yr; male; informed consent
Exclusion criteria
Exclusion criteria: Patients-related factors: recent myocardial infarction within 30 days; unstable angina with elevated CK-MB or cTnI; previous cardiac surgery; abnormal renal function; abnormal liver function; left ventricular ejection fraction of =35%; previous stroke. Perioperative factors: currently or recently taking immunosuppressive agents; use of radiocontrast agents within 7 days before surgery; preoperative white blood cell count 10 x10^9/L; emergency operations; planned simultaneous surgery; a second cardiac surgery during the same hospital stay; intraoperative use of cardiopulmonary bypass (CPB); discontinuation of postoperative tropisetron infusion; receive systemic steroids in the perioperative period; perioperative use of intra-aortic balloon pump (IABP); perioperative infection; surgical site infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum interleukin-8;Serum interleukin-6;White blood cell count; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maximal percentage of serum creatinine increase compared to baseline;Serum Cardiac Troponin-I (cTnI);Serum CK-MB;Urinary Kidney Injury Molecule-1 (KIM-1); | — |
Countries
China
Contacts
Public ContactChao Xiong
Beijing Chao-Yang hospital
Outcome results
None listed