Hand and foot skin reaction
Conditions
Interventions
experimental group:Apatinib+external Chinese medicine+hand and foot skin reaction routine therapy
control group:Apatinib+hand and foot skin reaction routine therapy
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years male and female; 2. Patients with Grade 1 or greater hand-foot skin reactions (according to NCI-CTC 4.0 criteria) after receiving apatinib monotherapy; 3. Karnofsky performance status (KPS)>70; 4. No serious heart, liver, kidney and other visceral function dysfunction; 5. Life expectancy more than 3 months; 6. For women of child-bearing age, the pregnancy test results (serum or urine) within 7 days before enrollment must be negative. They will take appropriate methods for contraception during the study until the 8th week post the last administration of study drug; 7. Subjects volunteered to join the study and signed the informed consent. Willing to and ability to comply with scheduled visits,treatment plans, laboratory tests, and other study procedure.
Exclusion criteria
Exclusion criteria: 1. Patients with hand-foot skin lesions or history of drug contact allergy before apatinib treatment; 2. Patients were receiving chemotherapeutic or nonchemotherapy drugs which may cause neurotoxicity; 3. Patients have symptoms of nerve compression due to brain metastases or limb metastases, or diseases of the nervous system caused by electrolyte disturbances and other systemic diseases(severe diabetes); 4. Patients have received hormones, Vitamin B and other therapy; 5. The infections or metabolic diseases were uncontrolled; 6. Evidence of significant medical illness that in the investigator's judgment will substantially increase the risk of Clinical research and determination of results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the response for 1 month; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life score;progression-free survival; | — |
Countries
China
Contacts
Public ContactJie-Er Ying
Zhejiang Cancer Hospital
Outcome results
None listed