Severe Traumatic Brain Injury
Conditions
Sponsors
Department of Neurosurgery, 101th Hospital of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years old male or female 2. sTBI(GCS3-8 points) patients and need craniotomy; 3. patients family members agree to ICP monitoring and other multiple monitoring; 4. Patients and their families have informed consent and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe systemic multiple injuries, main injury site is not in the brain; 2. Serious?underlying diseasespharmacohistory like aspirin maybe change outcome of operation; 3. Give up treatment as money or other factors not clinical condition; 4. Those who cannot complete the study plan; 5. Researchers consider anyone that not suitable for selection, as any reasons; 6. Non informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day all-cause mortality;3-month GOSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative acute encephalitis;postoperative complications;ICP and PI;Concentration of NSE, AQP4, TNF-a, vWF and Catecholamine; | — |
Countries
China
Contacts
Public ContactYuhai Wang
Department of Neurosurgery, 101th Hospital of PLA, China?
Outcome results
None listed