Diabetic retinopathy
Conditions
Interventions
one cohort:hMSC-RPE cells transplantation
Sponsors
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years male and female; 2. Clinical diagnosis is diabetic retinopathy with one or double visually impaired eyes; 3. There is no other ophthalmic diseases except diabetic retinopathy; 4. Conventional therapies are not effective for the diabetic retinopathy treatment; 5. Good function situation of immportant organsand No systemic infection; 6. Non tumor patient; 7. Patient with a history of anaphylaxis; 8. Patient without immunodeficiency disease; 9. Having signed informed consent papers; 10. Patient and family members agree to cooperate follow-up with good compliance.
Exclusion criteria
Exclusion criteria: 1. Suffering from other ophthalmic diseases besides diabetic retinopathy; 2. Progressive Cataract causing difficulty of retina examination; 3. Any eye surgery other than cataract surgery within previous 3 months; 4. History of retina detachment repair in the study eye; 5. Uveitis or other intraocular inflammatory disease in the study eye; 6. Participation in any clinical trial of a drug by ocular or systemic administration within the latest 6 months; 7. History of malignancy; 8. History of myocardial infarction, liver function failure and kidney function failure; 9. Suffering from immunodeficiency or Any current immunosuppressive therapy and corticosteroid treatment; 10. A history of allergies; 11. Pregnant women; 12. Any other condition that affects patient compliance, patient safety, and the outcome of this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early treatment of diabetic retinopathy eye chart (ETDRs);Fluorescein angiography;Optical coherent tomography (OCT);Flash electroretinogram (FERG);fundus photography;Best corrected visual acuity;Multifocal ERG;HRA autofluorescence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anterior segment image;Intraocular pressure;microperimetry;Center and peripheral field of vision or Humphrey 24-2;A or B-ultrasound;Corneal endothelial count; | — |
Countries
China
Contacts
Public ContactZhao Zhenlin
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
Outcome results
None listed