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The clinical effect of dexamethasone in peri-operative period of total hip/knee arthroplasty under the management of enhanced recovery after surgery: a prospective, randomized, controlled trial

The clinical effect of dexamethasone in peri-operative period of total hip/knee arthroplasty under the management of enhanced recovery after surgery: a prospective, randomized, controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1800016865
Enrollment
Unknown
Registered
2018-06-30
Start date
2018-06-28
Completion date
Unknown
Last updated
2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip and knee joint disease

Interventions

A:dexamethasone: prior to anesthesia induction (10mg), after surgery (10mg)
B:dexamethasone:prior to anesthesia induction (20mg)

Sponsors

Department of Orthopaedics, West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) need total hip/knee arthroplasty for end stage joint disease, and >18 years old; (2) volunteers with good compliance and had been informed consent.

Exclusion criteria

Exclusion criteria: 1. reversion or bilateral arthroplasty; 2. had glucocorticoid in last 3 months; 3. rheumatoid diseases, systemic lupus erythematous, ankylosing spondylitis; 4. the affected joint had severe deformity; 5. with severe liver and kidney function deficiency; 6. contraindication in using glucocorticoid.

Design outcomes

Primary

MeasureTime frame
VAS;opioids consumption;rate of nausea and vomiting;CRP;IL-6;—

Secondary

MeasureTime frame
range of motion;length of stay;—

Countries

China

Contacts

Public ContactFuxing Pei

West China Hospital, Sichuan University

809084355@qq.com+86 13560370152

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026