Hepatic ischemia-reperfusion injury
Conditions
Interventions
RIPC group:ischemic preconditioning on right arm
IPC group:10-min liver ischemia and 10-min ischemia reperfusion by the first porta hepatis before liver resection
Control group:a deflated cuff placed on the right upper arm for 30 min after anesthesia induction before surgery
Sponsors
Shanghai Eastern Hepatobiliary Surgery Hospital
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age <75; Liver function was basically normal, child a-b was not treated with chemotherapy, radiotherapy, radiofrequency, etc.; The first time of liver surgery.
Exclusion criteria
Exclusion criteria: 1. Major organ system diseases, such as heart infarction, COPD, cerebral infarction; 2. Peripheral vascular or neurologic diseases affect the sensory function of upper limbs; 3. The procedure is different from the expected method. 4. Intraoperative use of anti-inflammatory drugs such as glucocorticoid; 5. Previous history of liver surgery, intervention, radiofrequency or chemotherapy; 6. Refusal to participate in the experiment; 7. Mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver biochemistry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;ICGK; | — |
Countries
China
Contacts
Public ContactFeixiang Wu
Shanghai Eastern Hepatobiliary Surgery Hospital
Outcome results
None listed