Effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing cesarean section by combined spinal-epidural anesthesia

Study on effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing cesarean section by combined spinal-epidural anesthesia

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800016831

Enrollment

Unknown

Registered

2018-06-27

Start date

2018-07-01

Completion date

Unknown

Last updated

2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-dural puncture headache

Interventions

A:Patients were intravenously infused with 250mg aminophylline melted in 100 ml normal saline by thirty minutes after the fetus was removed.

C:The same volume of saline

Eligibility

Sex/Gender

Female

Age

24 Years to 38 Years

Inclusion criteria

Inclusion criteria: One hundred and twenty ASA I or II patients aged 24-38yr and pregnancy 38-42 weeks with single LOA at no birth undergoing cesarean section by combined spinal-epidural anesthesia randomly allocated into two groups(n=60 each)

Exclusion criteria

Exclusion criteria: The patients had no history of intraspinal puncture, no contraindications (such as coagulation dysfunction, spinal malformation, infection of puncture site, etc.), normal liver and kidney function, no cardiovascular system, respiratory system diseases, no diseases of nervous system,and no history of drug hypersensitivity. Intraoperative bleeding larger than 500ml and failure of spinal canal puncture (epidural or spinal needle puncture failure) were excluded from this study.

Design outcomes

Primary

Measure	Time frame
Post-dural puncture headache;	—

Countries

China

Contacts

Public ContactWang Wei

Jiangning Hospital Affiliated to Nanjing Medical University

wangwei2024@163.com+86 13851885625

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026