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Relationship between Intestinal microflora and cellular immunosuppression in patients with spinal cord injury

Relationship between Intestinal microflora and cellular immunosuppression in patients with spinal cord injury

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016823
Enrollment
Unknown
Registered
2018-06-27
Start date
2018-06-30
Completion date
Unknown
Last updated
2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal cord injury

Interventions

Spinal cord injury :none

Sponsors

Chengdu Military General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The spinal cord injury group: 1. All patients diagnosed with spinal cord injury in Chengdu Military general hospital will be included in this sampling crowd; 2. There were no other gastrointestinal diseases; 3. Antibiotics and probiotics were not used in the past month; 4. Inpatient patients who are able to cooperate with the study and not have serious heart, liver and kidney disease; 5. The subjects themselves or their immediate relatives knew and signed informed consent. The health control group: 1. From healthy subjects, matched with SCI group for age and gender, health examination confirmed that belong to the scope of health, do not suffer from any serious organic or functional diseases; 2. There were no other gastrointestinal diseases; 3. Antibiotics and probiotics were not used in the past month; 4. They volunteered to participate in this study and signed it on the informed consent form.

Exclusion criteria

Exclusion criteria: Exclusion criteria for spinal cord injury group: 1. Does not conform to the diagnostic criteria for spinal cord injury; 2. Combined with other gastrointestinal diseases; 3. Antibiotics and probiotics have been used in nearly a month; 4. Now suffering from or previously suffering from mental illness such as depression, anxiety, substance abuse, etc.; 5. There are serious complications, such as respiratory failure, heart failure, acute myocardial infarction, renal failure, liver failure, serious lung infection, and cancer have serious impact on the quality of life of patients with SCI; 6. Can not cooperate with the completion of this researcher. The exclusion criteria of the healthy control group: 1. The health examination was not qualified; 2. Combined with other gastrointestinal diseases; 3. Antibiotics and probiotics have been used in nearly a month; 4. Now suffering from or previously suffering from mental illness such as depression, anxiety, substance abuse, etc.; 5. Unable to cooperate with the completion of the researchers.

Design outcomes

Primary

MeasureTime frame
gut micrbiota;short chain fatty acid;T lymphocyte subsets and NK cells;

Countries

China

Contacts

Public ContactPang Ri-Zhao

Chengdu Military General Hospital

164156247@qq.com+86 18980020187

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026