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The mechamism and effect of cardiac stem cell-derived µ opioid receptor mediated protection by morphine preconditioning on the failing heart against post-ischemia reperfusion injury via Caveolin-3/MG53 signal pathway

The mechamism and effect of cardiac stem cell-derived µ opioid receptor mediated protection by morphine preconditioning on the failing heart against post-ischemia reperfusion injury via Caveolin-3/MG53 signal pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016797
Enrollment
Unknown
Registered
2018-06-25
Start date
2018-06-30
Completion date
Unknown
Last updated
2021-05-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic heart failure

Interventions

Normal and heart failure group:No

Sponsors

The Second Hospital of Anhui Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Patients undergoing cardiopulmonary bypass for cardic sugery; (2) Aged 18 to 60 years; (3) BMI ranged for 18.5~30 kg/m2; (4) ASA I-IV.

Exclusion criteria

Exclusion criteria: (1) Serious history of brain, lung, liver, kidney and metabolic diseases; (2) Severe complications and infectious diseases; (3) Major mental dysfunction; (4) Hepatitis,syphilis and other infectious diseases.

Design outcomes

Primary

MeasureTime frame
The expression level of opioids expression;The expression level of protein;—

Countries

China

Contacts

Public ContactJin Shiyun

The Second Hospital of Anhui Medical University

xingzheruyun@126.com+86 0551-63869485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026