postoperative delirium
Conditions
Interventions
Group D:PCIA: 4.8 µg/kg dexmedetomidine, 2 µg/kg sufentanil and 6 mg tropisetron diluted with 0.9% normal saline to 96 mL
Group C:PCIA: 2 µg/kg sufentanil and 6 mg tropisetron diluted with 0.9% normal saline to 96 mL
Sponsors
Xuzhou Medical University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) scheduled to undergo major elective noncardiac surgery (including spine, orthopedic, urologic, thoracic, or general surgery) under general anesthesia without a planned ICU stay; (2) agree to use of patient-controlled intravenous analgesia pump; (3) Aged =65 years; (4) American Society of Anaesthesiologist physical status classification I to III; (5) Mini Mental State Examination (MMSE) =20 points
Exclusion criteria
Exclusion criteria: (1) emergency surgery; (2) intracardiac or intracranial surgery; (3) inability to communicate because of severe vision or hearing impairment; (4) sick sinus syndrome, clinically significant sinus bradycardia, or second-degree or higher heart block in the absence of a pacemaker; (5) serious liver dysfunction (Child–Pugh class C) or serious kidney failure (requiring dialysis); (6) previous history of schizophrenia, epilepsy, Parkinson’s disease, or myasthenia gravis; (7) allergy to a2-adrenergic agonist or opioids; (8) prior recruitment in other clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of extubation;The percentage of patients requiring flurbiprofen axetil for pain rescue and the total consumption of flurbiprofen axetil;length of stay in hospital after surgery;Incidence of non-delirium complications after surgery;Adverse events;Pain intensity;subjective sleep quality;All-cause 30-day mortality after surgery; | — |
Countries
China
Contacts
Public ContactShen Wen
Xuzhou Medical University
Outcome results
None listed