Ulinastatin's Effect on Vascular Endothelial Glycocalix layer of The Patients Undrgoing Liver-transplantation

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800016776

Enrollment

Unknown

Registered

2018-06-23

Start date

2018-06-22

Completion date

Unknown

Last updated

2018-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Injury of Vascular Endothelial Glycocalix layer

Interventions

Control Group:0.9%NaCl

U1 Group:20,000U/kg Ulinastatin ivgtt. before the surgery

U2 Group:10,000U/kgUlinastatin ivgtt. before the surgery, 5000U/h during the surgery

U3 Group:20,000U/kg Ulinastatin ivgtt. seperately during the surgery

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. patients undergoing liver transplantation; 2. ASA II-III; 3. Aged40-65years, BMI 18.5-30.5; 4. voluntary participation.

Exclusion criteria

Exclusion criteria: 1. Alcohol or substance abuse; 2. abnormal renal function SCr >707umol/L; 3. Sever Heart Disease (Acute myocardial infarction, heart failure (NYHA III/IV),etc); 4. Uncontrolled diabetes.

Design outcomes

Primary

Measure	Time frame
Syndecan-1;serum albumin;IL-6;	—

Countries

China

Contacts

Public ContactJiawan Wang

Beijing Chaoyang Hospital, Capital Medical University

bargitta_wjw@163.com+87 13581723651

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026