chronic obstructive pulmonary disease
Conditions
Interventions
Optimized group:Noninvasive positive pressure ventilation under the optimization of noninvasive positive pressure ventilation parameter strategy+ oxygen therapy
control group:Noninvasive positive pressure ventilation (clinical experience) + oxygen therapy
Reference group (Guangzhou Panyu Central Hospital):Noninvasive positive pressure ventilation (clinical experience) + oxygen therapy
Sponsors
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 40-80 years old; 2. Meet COPD diagnostic criteria; 3. The diagnosis was in line with AECOPD (defined as an acute change in a patients baseline dyspnoea, cough and/or sputum beyond day-today variability sufficient to warrant a change in therapy), and accompanied by respiratory acidosis (pH = 7.35, PaCO2> 50 mmHg).
Exclusion criteria
Exclusion criteria: 1) cardiac and respiratory arrest; 2) progressively worsening disease in spite of NIV administration; 3) the need to protect the airways; 4) hemodynamic instability (for example, heart rate < 50 beats/minute with loss of alertness, and/or systolic blood pressure < 70 mmHg); 5) agitation and inability to tolerate the mask; 6)Excludes malignant tumors, severe bronchiectasis , pulmonary embolism and other patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Arterial blood pH; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial blood carbon dioxide partial pressure(PaCO2);Arterial blood oxygen partial pressure(PaO2);Respiratory rate;tidal volume (Vt);Failure rate;Peripheral oxygen saturation(SpO2);Heart rate; | — |
Countries
China
Contacts
Public ContactChen Rongchang
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affliated Hospital of Guangzhou Medical University
Outcome results
None listed