Immunological rejection of allogenic skin transplantation
Conditions
Interventions
case series:T cell vaccination
Sponsors
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
Eligibility
Sex/Gender
All
Age
6 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 6-60 years old; 2. Patient with autologous skin deficiency needs allogeneic skin to cover wounds; 3. Good function situation of immportant organs; 4. No systemic infection; 5. Non tumor patient; 6. Patient with a history of anaphylaxis; 7. Patient without immunodeficiency disease; 8. Having signed informed consent papers; 9. Patient and family members agree to cooperate follow-up with good compliance.
Exclusion criteria
Exclusion criteria: 1. Skin trauma with other complex visceral injuries; 2. Severe large area burns with multiple organ failure; 3. Patients who need skin grafts and have sufficient syngeneic donors; 4. Cancer patients; 5. Patients with autoimmune deficiency or other acquired,congenital immunodeficiency diseases; 6. Patients with a history of allergy; 7. Patients with long-term use of hormones and immunosuppressive agents; 8. Pregnant or lactating women; 9. Participated in clinical trials of other drugs within one month; 10.History of Organ Transplantation; 11.According to the investigator's judgment, there are serious concomitant diseases that endanger the patient's safety or affect the patient's completion of the study; 12. Patients who did not sign informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Graft Survival Time;Histology;CD4+ T cells;CD8+ T cells;Regulatory T cells;CD28+ T cells;Bilirubin;Glutamic-Pyruvic Transaminase;CRP;Neutrophil count; | — |
Countries
China
Contacts
Public ContactZhao Zhenlin
Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine
Outcome results
None listed