Postoperative cognitive impairment
Conditions
Interventions
Elective extracorporeal circulation Coronary artery bypass grafting patients:Nil
Non-Elective extracorporeal circulation Coronary artery bypass grafting patients:Nil
Sponsors
Shandong Provincial Qianfoshan Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) patients meeting the diagnostic criteria of CHD; (2) patients with diffuse coronary stenosis with >75% of the degree of vascular stenosis and CABG at the selected time; (3) preoperative simple intelligent scale (MMSE) test without cognitive impairment: >17 points for illiteracy, >20 points for primary school (education years less than 6 years), and >25 points for junior middle school and above; (4) after CABG surgery, the degree of vascular stenosis was significantly improved, and angina and cardiac dysfunction were effectively relieved; (5) participate in the test voluntarily and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) preoperative MMSE test has cognitive dysfunction (illiteracy is no more than 17 points, primary school is no more than 20 points, middle school is no more than 25 points); (2) have or have a history of severe central nervous system diseases or mental diseases (stroke, transient ischemic attack, cerebral ischemic attack, severe anxiety disorder, drug addiction, etc.); (3) have a history of brain surgery; (4) those who are taking neuro-psychiatric drugs; (5) people with severe hearing or visual impairment who are unable to carry out cognitive function tests; (6) patients with other cardiovascular diseases requiring concurrent surgery; (7) heavy alcoholics; (8) refuse or have participated in other experimental studies, and cannot complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GFAP;Aß42; | — |
Countries
China
Contacts
Public ContactSun Yongtao
Shandong Provincial Qianfoshan Hospital
Outcome results
None listed