Nausea and vomiting caused by chemotherapy of DP regimen in cancer patients
Conditions
Interventions
Case series:Aprepitant delayed administration
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 74 Years
Inclusion criteria
Inclusion criteria: (1) Adult males or females older than 18 years of age; (2) Patients diagnosed with malignant solid tumors after histopathological examination; (3) No medical treatment after diagnosis (chemotherapy, radiotherapy, molecular targeting, immunization) Etc.); (4) can accept high emetogenic DP regimen chemotherapy (docetaxel 75mg/m2 d1 + cisplatin 25mg/m2 d1-3), and before and after the two cycles of chemotherapy drug dose and adjuvant drugs are the same;; (5) No diabetes, peptic ulcer, no serious organ failure and immune deficiency, normal blood and liver, kidney function and electrolytes; (6) No vomiting within 24 hours before chemotherapy, and no other antiemetics And sedatives; (7) No brain metastases; (8) Observing and signing informed consent forms, which can actively cooperate with treatment and blood collection.
Exclusion criteria
Exclusion criteria: (1) Nausea and vomiting have occurred within 24 hours before chemotherapy; (2) Nausea and vomiting caused by primary central nervous system malignancies, central nervous system metastases, gastrointestinal obstruction, and radiotherapy; (3) Benzodiazepines are being used. Zhuo, dexamethasone and other sedative medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical index;Blood concentration; | — |
Countries
China
Contacts
Public ContactMa Jin-An
The Second Xiangya Hospital of Central South University
Outcome results
None listed