spinal cord injury
Conditions
Interventions
low intensity exercise treatment group:conventional therapy and low intensity exercise
moderate intensity exercise treatment group:conventional therapy and moderate intensity exercise
high intensity exercise treatment group:conventional therapy and high intensity exercise
control group:conventional therapy
Sponsors
The First Affiliated Hospital, Nanjing Medical University (Jiangsu Province Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. confirmed by CT or MRI, the flat surface of the spinal cord was T7-L1, AIS B and AIS C(ASIA grade); 3. the course of the disease was 3-12 months, and there were different degrees of lower limb spasm; 4. passive range of hip and knee joints was approximately normal and did not affect Motomed treadmill training; 5. patients can understand and actively participate in the training program, agreed and signed the informed consent of the clinical study; 6. if anti-spasticity drugs were used, the stability use of the drug like dosage had already used for more than 1 month.
Exclusion criteria
Exclusion criteria: 1. ischemic heart disease, arrhythmia, unstable angina; 2. severe chronic obstructive pulmonary disease; 3. combined with lower extremity fractures; 4. combined with peripheral nerve injury of the lower extremities; 5. combined history of stroke; 6. severely limited range of motion of joints, limited Motomed treadmill training; 7. Pregnancy or breastfeeding women; 8. Need to use nerve blockage at any time during the trial; 9. Neurotranscision such as botulinum toxin or alcohol within 3 months before the start of the trial.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| H - Max/M - Max ratio;RDD value;motor evoked potential (MEP);somatosensory evoked potential (SEP); | — |
Primary
| Measure | Time frame |
|---|---|
| ASIA grade;Lower limb muscle strength;activity of daily living (ADL);Modified Ashworth Scale (MAS);Modified Tardieu Scale (MTS);Brain-derived Neurotrophic Factor (BDNF);calcium/cyclic-AMP responsive binding protein (CREB); | — |
Countries
China
Contacts
Public ContactWang Hongxing
The First Affiliated Hospital, Nanjing Medical University (Jiangsu Province Hospital)
Outcome results
None listed