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Identification of biomarkers for glaucoma in the tear film by next generation proteomic technology

Identification of biomarkers for glaucoma in the tear film by next generation proteomic technology

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016582
Enrollment
Unknown
Registered
2018-06-01
Start date
2018-06-29
Completion date
Unknown
Last updated
2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma

Interventions

Gold Standard:Using ProteinPilot 5.0 software
protein&#32

Sponsors

The Chinese University of Hong Kong
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 60 Years

Inclusion criteria

Inclusion criteria: Control group subject inclusion criteria: 1. Chinese adults aged between 40-60 years; 2. Spectacle corrected monocular VA: 0.2 logMAR or better after full correction; 3. No contact lens wear; 4. Free of ocular and systemic abnormalities e.g. cataract, diabetes mellitus (DM) Intraocular pressure (IOP): 21 mmHg or less in both eyes; 5. Difference in IOP between two eyes: 3 mmHg or less; 6. Able to give written consent. Newly diagnosed glaucoma group subject inclusion criteria: 1. Early onset of signs of primary open-angled glaucoma (POAG); 2. Intraocular pressure (IOP): 22 mmHg or more in one or both eyes; 3. Sign of optic nerve abnormalities according to the classification of Mild or Early Stage Glaucoma in the Glaucoma ICD-10 quick reference guide of the American Academy of Ophthalmology (AAO); 4. Free from other ocular and systemic diseases e.g. cataract, DM etc.; 5. Able to give written consent.

Exclusion criteria

Exclusion criteria: 1. Regular contact lens wear; 2. DM, severe heart disease, history of stroke; 3. Dry eye disease; 4. Underwent LASIK surgery.

Design outcomes

Primary

MeasureTime frame
Differentially protein expressions;

Countries

China

Contacts

Public ContactProf. Leung Kai Shun Christopher

The Chinese University of Hong Kong

cksleung@cuhk.edu.hk+852 39435825

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026