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regulation in psoriasis

To study the mechanism of the blood-heat clearing and detoxicating formula in psoriasis from the view of transcriptional regulation of miR-451 during T cell differentiation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016573
Enrollment
Unknown
Registered
2018-06-10
Start date
2018-07-02
Completion date
Unknown
Last updated
2018-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

psoriasis

Interventions

Blood heat type:LiangXueJieDu Decoction
non-blood-heat psoriasis:none
healthy control group:none

Sponsors

Beijing Hospital of TCM affliated to CMU
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The included individuals must comply with all the following criteria; 1. Psoriasis group: 1) Meeting the clinical diagnosis criteria of psoriasis; 2) Male or female patients aged; 3) Aged 18-65 years old; 4) Written informed consent for participating; 5)For blood-heat type psoriasis, meeting the clinical diagnosis criteria of psoriasis blood-heat syndromes of T.C.M.; 2. Control group: 1) Healthy, nonpsoriatic volunteers; 2) Male or female patients aged 18-65 years old; 3) Written informed consent for participating.

Exclusion criteria

Exclusion criteria: 1) Obscure in syndrome differentiation, not belonging to blood-heat syndromes; 2) Pregnant and lactating women; 3) Taking corticosteroids, phototherapy, systemic therapies and other T.C.M. treatment within 4 weeks; Use of corticosteroids, vitamin D analogues, keratolytics or coal tar within 2 weeks; 4) Renal or liver impairment, active infection, immunosuppression or other serious concomitant illness; 5) Accompany with skin tumor; 6) Patients with erythrodermic, pustular, and only palmoplantar forms of psoriasis, and patients with psoriatic arthritis were excluded; 7) Allergic to components of the decoction.

Design outcomes

Primary

MeasureTime frame
PASI (psoriasis area and severity index);T cell subset;gene expression;molecular pathology;

Countries

China

Contacts

Public ContactYajun Li

Beijing Institution of TCM, Beijing Hospital of TCM affliated to CMU

liyj1102big@126.com+86 010 52176965

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026