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Effects of Anesthesia Exposure in Infants and Early Childhood on Mid-long-term Term Cognitive Function of Developing Brain

Effects of Anesthesia Exposure in Infants and Early Childhood on Mid-long-term Term Cognitive Function of Developing Brain

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016530
Enrollment
Unknown
Registered
2018-06-06
Start date
2018-06-01
Completion date
Unknown
Last updated
2018-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

clinical anesthesia

Interventions

control group:no

Sponsors

Children's Hospital of Nanjing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 12 Years

Inclusion criteria

Inclusion criteria: Experimental group: Children who were under general anesthesia and had stable intraoperative vital signs during the period from January 2008 to December 2012 (within 2 years of age). Control group: Normal children of the same age who had not experienced surgery and anesthesia within the age of 2 years and the rest criteria were the same as the experimental group.Both groups signed written informed consent.

Exclusion criteria

Exclusion criteria: (1) Parents refuse to participate in this study; (2) Abnormal maternal pregnancy: including mothers diagnosed with moderate-to-severe high-pregnancy hypertension, severe gestational diabetes, moderate-to-severe gestational anemia, and poor contact (rays, medications, heavy metals, etc.); (3) Perinatal abnormalities or complications: including premature birth, low birth weight, neonatal asphyxia (Apgar score =7 points at 1 or 5 minutes after birth), postpartum neonatal ICU, and delivery-related head complications Symptoms (including neonatal head hematoma, intracranial hematoma, intraventricular hemorrhage, etc.), neonatal pathological jaundice, etc.; (4) Congenital malformations: including congenital heart disease, hydrocephalus, spina bifida, etc.; (5) Acquired diseases that affect mental development: including mental disorders such as central nervous system infections, trauma history, epilepsy, and schizophrenia; (6) There are intellectual disabilities, schizophrenia, manic depressive psychosis, etc. in family history; (7) Loss of contact, eviction or death.

Design outcomes

Primary

MeasureTime frame
WISC-1V, full scale IQ;WISC-1V, different cognitive dimensions;

Secondary

MeasureTime frame
IVA-CPT;SNAP-?;Child Behavior Check List, CBCL;Sensory Integration Theory;Japanese S-M social life ability scale;

Countries

China

Contacts

Public ContactXiaoping Gu

Children's Hospital of Nanjing Medical University

xiaopinggu1@gmail.com+86 13813996903

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026