severe type II aplastic anemia
Conditions
Interventions
Case series:allogeneic bone marrow transplantation
Sponsors
Department of Hematology, Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) must be able to understand the test plan, comply with the doctor's advice, and sign informed consent; 2) Aged 2 to 60 years old. 3) according to the diagnostic criteria of severe aplastic anemia type II: the patients with chronic aplastic anemia had two of the following three items: the absolute value of reticulocyte 5/10) haplotype donors, donor aged 8-65 years old, no contraindication of donor (except for hematological diseases, malignant tumors, infectious diseases, severe organ dysfunction, mental illness, etc.); 12) no active infection; 13) the pregnancy test for women of childbearing age must be negative, and agreed to use effective contraception during treatment and subsequent one year.
Exclusion criteria
Exclusion criteria: 1) exclude paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and congenital genetic diseases; 2) combined with serious heart and lung liver and kidney disease; 3) specific allergic constitution and intolerance to medication; 4) active HBV hepatitis, HCV antibody positive; 5) serious disease which may be restrictions of the patient's participation (e.g., progressive infection and / or active infection, drug-resistant bacterial infection, septicemia, non controlled diabetes, severe cardiac insufficiency or angina, and liver and kidney insufficiency); 6) participating in other clinical trials or participating in other drug clinical trials within 3 months; 7) women who laced or did not take effective contraception or pregnancy; 8) the mental state is unstable; 9) the researchers believe that patients who are not suitable for this treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EFS of 1 year;30 day implantation rate;100 day implantation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 year OS;TRM; | — |
Countries
China
Contacts
Public ContactYan Jinsong
Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed