parkinson disease
Conditions
Interventions
A:after activation of the implantable pulse generator,bilateral stimulation frequencies are set divergently(More than 30Hz difference) for 3 months,then set at the same level(same frequency number) f
B:after activation of the implantable pulse generator,bilateral stimulation frequencies are set at the same level(same frequency number) for 3 months,then set at divergently(More than 30Hz difference)
Sponsors
Neurosuegery Department, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Idiopathic Parkinsons disease, in according with 2016 China diagnostic criteria for Parkinson's disease; 2. Levodopa Responsiveness improvement rate more than 30%; 3. Aged between 18-65 years old; 4. Medical Treatment is ineffective, even by further adjustment of therapeutic schedule; 5. Medical Treatment is effective, but patients can't bear the side effect within that dose (for example, severely disabling involuntary movement); 6. Dysfunction not responsive to medical treatment severely interferes with daily life; 7. patient or statutory guardian signs informed consent, with good compliance and cooperation with the follow-up.
Exclusion criteria
Exclusion criteria: 1. obviously affective disorder or phrenoblabia; 2. nervous system disease, such as epilepsy, brain trauma,brain tumor, severe cerebral infarction, alzheimer's disease, etc.; 3. people forbidden to MRI scan , for example with metal implantation materials; 4. All surgical contraindications (anticoagulants,terminal cancer, infectious disease and immuno-deficiency, etc.); 5. Pregnant or lactating women; 6. serve cognition impairment,incapable of cooperating with surgery and follow up; 7. Any situation endangering patient and it's successfully participation of the research program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Pakinson's Disease Rating Scale part II and III;Montreal cognitive assessment;Hamilto Anxiety;Hamilton Depression Scale;Unified Dyskinesia Rating Scale (UDysRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| 39-Item Parkinson's Disease Questionnaire;Minimum Mental State Examination; | — |
Countries
China
Contacts
Public ContactWang Wei
Neurosuegery Department, West China Hospital, Sichuan University
Outcome results
None listed