Colorectal cancer
Conditions
Interventions
Chemotherapy and placebo group:Placebo
Chemotherapy and probiotic group:Oral probiotics
Non-chemotherapy and placebo group:Placebo
Non-chemotherapy and probiotic group:Oral probiotics
Sponsors
Changzheng Hospital; The Second Military Medical University of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Karnofsky score more than 80 points; 3. Received radical resection and pathological confirmed as colorectal cancer (stage I-III); 4. Not received neoadjuvant treatment; 5. No protective stoma. The patient and family members understood the study protocol and participated in the study voluntarily.
Exclusion criteria
Exclusion criteria: 1. Combined with other tumors or with colorectal cancer metastasis; 2. Combined with mental illness other than anxiety and depression; 3. Combined with alcoholism or drug addiction; 4. With history of cerebral ischemia or cerebral hemorrhage; 5. Combined with intestinal perforation, intestinal bleeding which require emergency surgery; 6. Pregnant or lactating women; 7. Patients taking immunosuppressants, glucocorticoids, opioids and anti-anxiety and depression drugs; 8. Unable to conplete the follow-up plan; 10. The patient or family cannot understand this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety and Depression Symptoms (HAD); | — |
Secondary
| Measure | Time frame |
|---|---|
| fMRI;State Trait Anxiety Scale (STAI);Chemotherapy side effects;Intestinal flora;Neurotransmitter;Neurotrophic factor;Metabolomics;Quality of postoperative life; | — |
Countries
China
Contacts
Public ContactLi Xinxing
Changzheng Hospital; The Second Military Medical University of PLA
Outcome results
None listed