negative diver gene advanced non-squamous non-small cell lung cancer
Conditions
Interventions
Case series:apatinib
Sponsors
Affiliated Hospital of Shandong Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years old; 2. performance status (PS) of 0 to 2; 3. The tumor is locally advanced or metastatic (Stage IIIB-IV), which is not suitable for radical surgery and radiotherapy; 4. The lesions can be measured (at least one can be evaluated according to the standard of RECIST 1.1 standard, namely, the longest diameter is at least 10mm; if the CT scan layer's thickness is greater than 5mm, the lesion diameter is twice as thick as the thickness of the layer; If the lesion is the lymph node, measure the short diameter at least 15 mm; 5. The main organ function meeting the following: blood routine examination meeting the standards:ANC=1.5×10^9/L; PLT=80×10^9/L; Hb=90g/L;blood biochemical examination meeting the following standards: TBIL45ml/min5.To be able to comply with the research and follow-up procedures; 6. The subject understands and voluntarily signs the written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with uncontrolled hypertension (systolic blood pressure = 140 mmHg or diastolic blood pressure = 90 mmHg, despite optimal drug therapy); 2. According to NYHA standard, III ~ IV cardiac insufficiency, or heart colour to exceed revealed left ventricular ejection fraction (LVEF) 1.5 or PT>ULN+4, or APTT>1.5 ULN), bleeding tendency or receiving coagulation therapy; 4. Before randomization within 3 months had significant bleeding clinical significance or definite bleeding tendency, such as gastrointestinal bleeding, bleeding gastric ulcer, hemoptysis and so on; 5. Radiological evidence (CT or MRI) indicates the presence of a central type of tumor invading local large vessels; 6. Central nervous system with symptoms of metastasis; 7. pregnant or lactating women8.Other patients who were considered unsuitable for inclusion by physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| DCR;AE; | — |
Countries
China
Contacts
Public ContactSheng Lijun
Affiliated Hospital of Shandong Academy of Mesdical Sciences
Outcome results
None listed