Major depressive disorder
Conditions
Interventions
active treatment group:transcranial Alternating Current Stimulation
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. A diagnosis of MDD is based on the Diagnostic and Statistical Manual of Mental Disorders,4th Edition,text revision (DSM-IV-TR), and confirmed with the mini international neuropsychiatric interview 5.0 in Chinese version by at least two attending physicians or upper level; 2. Aged 18-65 years old, male or female; 3. Unipolar, depressive disorder without psychotic symptoms; 4. The level of audiovisual is sufficient to complete the examinations required for the study; 5. The 17-item Hamilton Depression Rating Scale (HDRS-17) scores >17 points; 6. There are no contraindications for magnetic resonance imaging and magnetoencephalography scans; 7. All research content will be understood and informed consent will be signed.
Exclusion criteria
Exclusion criteria: Those who meet one of the following items cannot be enrolled: 1. A recent or past history of DSM-IV-TR axis I diagnoses besides unipolar major depression; 2. Axis-II diagnoses: antisocial personality disorder; 3. An obvious medical comorbidity; 4. Patients who have taken or are currently taking any antipsychotics or/and antidepressants and/or anxiolytics within 6 months prior to the enrollment; 5. Those who have had severe or unstable organic diseases; 6. Those who have brain-related diseases such as brain injury or intracranial infection; 7. Those who have had seizures, epilepsy, hydrocephalus or central nervous system tumors; 8. Those who have cochlear hearing aids, pacemakers, or implanted devices in the brain; 9. Those who have undergone electroconvulsive or transcranial magnetic stimulation or other neuromodulation techniques; 10. The score of item 3 (suicide) in HDRS-17 >=3 points; 11. The skin integrity of the electrode placement site is impaired or allergic to the electrode gel or adhesive; 12. Pregnant or lactating women, or those who are planning to become pregnant in the near future; 13. Those who are participating in any other clinical research within the first month of enrollment or are currently participating in any other clinical studies; 14. The investigator believes that there is a situation that is inappropriate for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportions of participants have improvements of 1, 2, and 3;proportion of participants having adverse event;a clinical response rate;A remission rate;change of depressive symptoms; | — |
Countries
China
Contacts
Public ContactYuping Wang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed