acute kidney injury
Conditions
Interventions
RCA-CRRT:regional citrate anticoagulation (RCA)
NA-CRRT:no anticoagulation (NA)
Sponsors
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 87 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were adult AKI patients of stage 3 according to KDIGO guideline, with high risk factors for bleeding including post-major surgeries involving heart, chest, abdomen, spine or brain, coagulopathy (PT or APTT > 1.5 times the normal control, or PT > 18s, APTT > 60s) and/or thrombocytopenia (< 50×10^9/L) induced by trauma, sepsis or active bleeding, and combined therapy with anticoagulant, antiplatelet or thrombolytic agents. The CRRT was initiated within 3 h after randomization.
Exclusion criteria
Exclusion criteria: severe liver failure (serum total bilirubin > 171 µmmol/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| filter survival;ICU survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| causes of filter replacement;systemic total calcium;systemic ionized calcium;post-filter ionized calcium;expense on CRRT;citrate concentration in systemic plasma;citrate concentration of post-filter plasma;citrate concentration of ultrafiltrate;CRRT supporting time;volume of packed red blood cells transfusion during CRRT;volume of platelet transfusion during CRRT;the ratio of total calcium/ionized calcium; | — |
Countries
China
Contacts
Public ContactJianping Gao
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed