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Effect of systemic inflammatory response on cognitive function in elderly patients after knee arthroplasty by resting-state fMRI

Effect of systemic inflammatory response on cognitive function in elderly patients after knee arthroplasty by resting-state fMRI

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016437
Enrollment
Unknown
Registered
2018-06-01
Start date
2018-06-01
Completion date
Unknown
Last updated
2018-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis of the knee

Interventions

Pt:Surgical stress
HC:None

Sponsors

Xuanwu Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. Elderly patients with OA (> 65 years old), right hand; 2. Unilateral knee arthroplasty, combined spinal-epidural anesthesia; 3. ASA III level or less; 4. Preoperative MMSE score >27.

Exclusion criteria

Exclusion criteria: 1. Severe Cardiopulmonary system disease, severe hypertension and poor control; 2. Specific nervous system disorders: cerebral infarction, intracranial tumor, 3. History of craniocerebral trauma, psychiatric and depression history; 4. History of alcohol and drug abuse; 5. History of severe diabetes, chronic kidney disease,liver disease; 6. History of alzheimer's disease and family history; 7. Contraindications of spinal anesthesia; 8. Contraindicationsof MRI; 9. Refuse to participate in research.

Design outcomes

Primary

MeasureTime frame
cognitive function;brain function connectivity ;—

Countries

China

Contacts

Public ContactWANG TIANLONG

Xuanwu Hospital, Capital Medical University

w_tl5595@hotmail.com+86 13910525304

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 17, 2026