Hirayama disease
Conditions
Interventions
no treatment:
surgical treatment:anterior cervical fusion procedures
Sponsors
Jiang Jianyuan
Eligibility
Sex/Gender
All
Age
14 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) insidious disease onset before 25 years of age; (2) unilateral or asymmetric weakness and amyotrophy of the distal upper extremities without sensory dysfunction or lower limb involvement with denervation that was limited to the unilateral or bilateral upper extremities and was identified using electrophysiological methods in addition to normal sensory nerve function; (3) with or without clinical symptoms, such as cold paralysis, fasciculation and tremor in the upper extremities, and (4) cervical-flexion magnetic resonance imaging (MRI) showing lower cervical compression that resulted from forward-shifting of the posterior dura and a crescent abnormality posterior to the dura.
Exclusion criteria
Exclusion criteria: (1) a history of syringomyelia, spinal cord tumour or abnormalities in the cervical vertebrae; (2) focal or multifocal neuropathy; (3) brachial plexus injury; (4) congenital muscular dystrophy; (5) cervical spondylotic amyotrophy; (6) a primary or concomitant disorder of the neuromuscular junction, or (7) concomitant trauma, inflammation or infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MUNE;dynamic F-wave;handgrip strength;DASH;MRI; | — |
Countries
China
Contacts
Public ContactJiang Jianyuan
Department of Orthopedics, Huashan Hospital, Fudan University
Outcome results
None listed