Venous thromboembolism
Conditions
Interventions
Control group:nothing
Tranexamic acid group:Preoperative and intraoperative application of tranexamic acid
Livashaban group:Oral rivaroxaban 8 h after surgery, applied 35 days after surgery
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18 to 80 years; 2. Patients diagnosed with lumbar spinal stenosis or lumbar spondylolisthesis requiring posterior decompression and interbody fusion; 3. Anesthesia Risk Rating Scale ASA1- Level 3.
Exclusion criteria
Exclusion criteria: 1. Patients with PE or DVT; 2. Patients with obvious liver diseases (such as hepatitis B, hepatitis C, acute hepatitis, chronic active hepatitis, cirrhosis); 3. Patients with creatinine clearance 180 mmHg or diastolic blood pressure> 110 mmHg or unsatisfactory blood pressure control; 6. Pregnant women, pregnant women or breast-feeding women who have not taken contraceptive measures; CYP3A4 potent inhibitors; 7. patients with acquired color vision disorders; 8. patients with thrombin; 9. patients with a history of convulsions; 10. patients with thrombophilic atrial fibrillation, stent implantation Patients, patients with cardiac pacemakers, etc.; 11. patients who require minimally invasive spine surgery; 12. patients with long-term oral antiplatelet drugs; 13. patients with long-term metformin use; 14. Hb<90g/L; 15. Patients with tranexamic acid or rivaroxaban allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bleeding volume during operation;bleeding volume after operation;Red blood count;Hemoglobin;D-dimer;Hematocrit;Prothrombin time;Activated partial thromboplastin time;Alanine aminotransferase;Aspartate transaminase;Creatinine;Urea nitrogen;Dual-leg vein ultrasound;Lumbar CT; | — |
Countries
China
Contacts
Public ContactYunzhen Chen
Department of Orthopedics, Qilu Hospital of Shandong University
Outcome results
None listed