small intestine injury
Conditions
Interventions
Case series:dual antiplatelet therapy
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. subjects with the age between 18 and 80 years; 2. subjects diagnosed as stable angina pectoris; 3. subjects who plan to use dual antiplatelet drugs after PCI at least June mouths; 4. subjects who agree to receive research treatment; 5. All subjects are voluntary and sign informed agreement.
Exclusion criteria
Exclusion criteria: 1. subjects receiving relevant drugs that have an impact on the experimental results in recent one month, the relevant drugs include: (1) antibiotics; (2) probiotics; (3) various drugs that inhibit gastric acid secretion (proton pump inhibitors and H2 receptor antagonists, etc.); (4) cytokines, immunosuppressants and cytotoxic agents; (5) hormones; (6) other drugs that affect the stomach biota. 2. subjects with capsule endoscopy for contraindications, including suspected or known gastrointestinal obstruction, stenosis, fistula, or diverticulum, a pregnant woman, a previous surgical operation of the digestive tract, or a change in the structure of the abdominal digestive tract, or refusing to accept any abdominal surgery (Once the capsule is in detention, it may need to be removed by surgery). 3. subjects taking other antiplatelet drugs or anticoagulant drugs at the same time; 4. PPI, mucosal protectant or other acid suppressant can not be restricted according to the regulations; 5. subjects diagnosed as acute coronary syndromes; 6. subjects with a history of peptic ulcers or hemorrhagic diseases; 7. peptic ulcer or gastrointestinal tumor was diagnosed by capsule endoscopy; 8. subjects who were allergic to aspirin, clopidogrel and polyethylene glycol electrolyte dispersion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;degree of small intestine mucous injury;Inflammatory factors;degree of gastric mucous injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Medical history;Combined use of drugs; | — |
Countries
China
Contacts
Public ContactZhang Jie
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed