stroke
Conditions
Interventions
bilateral treatment group:iTBS (1200 pulse, 60%-80% resting motor threshold (rMT), 400 seconds every day) over ipsilesional primary motor cortex (M1) and 1Hz (1200 pulse, 100%rMT, 24 minutes every day
unilateral treatment group: shamiTBS stimulation over ipsilesional M1 and 1Hz rTMS over contralesional M1
control group: shamiTBS stimulation over ipsilesional M1 and sham 1 Hz rTMS over contralesional M1
Sponsors
the First Hospital of China Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Unilateral or hemispherical ischemic or hemorrhagic stroke identified by CT or MRI.); (2) First onset, 30 to 60d after stroke, stable and progression free; (3) Aged 30 - 70 years old; (4) Except for a large area of infarct or hemorrhage in the frontotemporal lobe; (5) Mild or moderate stroke patients whose NIHSS score is less than 15 points; (6) The patient is willing to be treated with TMS.
Exclusion criteria
Exclusion criteria: (1) Combined with important organs such as heart, lung and kidney failure and those with intracranial hypertension; (2) Contraindication of repetitive transcranial magnetic stimulation: there are metallic foreign bodies in vivo, such as cardiac pacemakers, arterial stents, previous history of epilepsy, and skull defects; (3) Recent history of the use of drugs (sedatives and antidepressants) to alter cortical excitability; (4) Subjects who met the inclusion criteria but refused to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| upper extremity Fugl-Meyer Assessment (FMA); | — |
Secondary
| Measure | Time frame |
|---|---|
| motor evoked potential;Barthel index; | — |
Countries
China
Contacts
Public ContactYue-Wen Ma
The First Hospital of China Medical University
Outcome results
None listed