Primary pterygium
Conditions
Interventions
group 1:Pterygium excision combined with amniotic membrane transplantation
group 2:Excision of pterygium combined with conjunctival autograft with limbal stem cells
group 3:Pterygium excision combined with amniotic membrane transplantation and limbal stem cell transplantation
Sponsors
Beijing Tongren Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) aged 18-70 years men and women; (2) patients with pterygium surgery meet the following criteria: primary pterygium; The head of pterygium to the length of cornea < 4mm; (3) the laboratory results were in the following range: the upper limit of the normal value of aspartate aminotransferase (AST) below 1.5 times (ULN), the upper limit of the normal value of alanine aminotransferase (ALT) less than 1.5 times (ULN), and the upper limit of normal value of serum creatinine (Cr) less than 1 times (ULN); (4) voluntary signing of the letter of informed consent.
Exclusion criteria
Exclusion criteria: (1) lactating or pregnant women, or planned pregnancies; (2) other drugs that may affect the corneal epithelial growth and metabolism during the first 4 weeks of screening (such as befushu, gaintshu, Deproteinised Calf Serum Eye Gel, etc.); (3) patients with serious systemic organic diseases; (4) abnormal eye diseases such as eyelid, tear, conjunctiva and corneal stem cells, such as severe eyelid insufficiency, dry eye disease, and angular conjunctival chemical injury stem cell dysfunction are greater than those of 1/2 quadrant; (5) screening in the first 3 months to participate in or are participating in other clinical trials; (6) people with mental illness; (7) poor compliance; (8) the researchers believe that there are any patients who are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BUT;shirmmer test 1;Corneal epithelium healing;Recurrence of pterygium;Amniotic membrane dissolving; | — |
Secondary
| Measure | Time frame |
|---|---|
| vision; | — |
Countries
China
Contacts
Public ContactYing Jie
Eye department of Beijing Tongren Hospital, Capital Medical University
Outcome results
None listed