healthy person
Conditions
Interventions
group2:Administration: single intravenous injection
administration time: 60 s. Dosage: 2 mg/kg.
Sponsors
West China Hospital , Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) The subjects voluntarily signed the informed consent form of the trial; 2) Aged between 18~65 years, BMI 18 to 30, half males and half females; 3) ASA I, II; 4) Selective operation under general anesthesiawhich is non cardiothoracic surgery, non neurosurgery and non hepatologicaland duration=30 min and blood loss =1000 ml, and surgical subjects need tracheal intubation; 5) Laboratory and imaging findings are in normal range or abnormal but not clinical significance.
Exclusion criteria
Exclusion criteria: 1) People who have drug allergy history, allergic disease, allergic constitution; who have allergy history of narcotic drugs or drugs whos structure be similar to trial drugwho are suspected hereditary history of malignant hyperthermia; who are allergic to eggs, soybeans and their products; who have contraindications of study related drugs; 2) Pregnant, lactating women, or those who have pregnancy plans within 1 months (including male subjects); 3) Systolic pressure140 mmHg; Heart rate120 bpm; Postural hypotension subjects; 4) According to the Fridericia formula, the QT/QTc interval was significantly prolonged (male=470 ms, female =480 ms); 5) People with known or expected difficulty airway; 6) Cognitive dysfunction; 7) Coagulation disorders; 8) People who take any other drugs within two weeks before the beginning of the trial,;smoking, drinking and caffeinated beverages during the test period; 9) People who are suspected or confirmed history of alcohol or substance abuse; 10) People who participated in the drug trial (including the trial drug) within 3 months before the trialor who were repeatedly enrolled in this trial; 11) A sponsor or researcher who directly participates in the trial,or their family members; 12) People who are refused by researchers with any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MOAA/S;central nervous system;circulatory system;respiratory system;liver function;renal function; | — |
Secondary
| Measure | Time frame |
|---|---|
| eyelash reflexes;BIS;recovery time;laboratory inspection;temperature; | — |
Countries
China
Contacts
Public ContactZhaomeng Wu
West China Hospital, Sichuan University
Outcome results
None listed