Hirayama Disease
Conditions
Interventions
surgical group:surgical treament
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) insidious disease onset before 25 years of age; (2) unilateral or asymmetric weakness and amyotrophy of the distal upper extremities without sensory dysfunction or lower limb involvement, with denervation that is limited to the unilateral or bilateral upper extremities and is identified by electrophysiological methods, with normal sensory nerve function; (3) gradually slower clinical progression after a relatively rapid initial progression; (4) clinical symptoms (which may or may not be present) such as cold paralysis, fasciculation or tremor of the upper extremities; and (5) cervical-flexion magnetic resonance imaging (MRI) showing lower cervical compression resulting from forward shifting of the posterior dura and a crescent abnormality posterior to the dura
Exclusion criteria
Exclusion criteria: (1) history of syringomyelia, spinal cord tumor, or abnormalities of the cervical vertebrae; (2) focal or multifocal neuropathy; (3) brachial plexus injury; (4) congenital muscular dystrophy; (5) cervical spondylotic amyotrophy; (6) primary or concomitant disorder of the neuromuscular junction; or (7) concomitant trauma, inflammation or infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MUNE; | — |
Countries
China
Contacts
Public ContactJiang Jianyuan
Huashan Hospital, Fudan University
Outcome results
None listed