Chronic Congestive Heart Failure
Conditions
Interventions
treatment group:Allisartan Isoproxil Tablets
control group:perindopril Tablets
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) male or female; 2) aged 18 to 75 years old; 3) chronic congestive heart failure, left ventricular ejection fraction (EF) <45%; 4) sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is more than 2 times the normal limit; 2) serum creatinine >176.8 and mol/L; 3) clear angiotensin receptor antagonists, angiotensin converting enzyme inhibitors, calcium channel antagonists or thiazide diuretics use contraindications; 4) previous history of mental illness; 5) pregnancy or lactation, or planned pregnancy (e.g., female); 6) after organ transplantation; 7) other serious diseases, such as malignant tumor, are not suitable for the study of the researcher;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction;Left ventricular diastolic diameter;Left ventricular systolic diameter;Left ventricular mass index;6 minute walk distance;pulmonary artery pressure;Major adverse cardiac events;Renin;Angiotensin ?;Aldosterone;BNP/NT-proBNP; | — |
Countries
China
Contacts
Public ContactZhao Liang-ping
The Second Affiliated Hospital of Soochow University
Outcome results
None listed