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Effects of Toll like receptor 2 ligands on mRNA expression of chemokine form human peripheral blood mononuclear cells from patients with atopic dermatitis

Effects of Toll like receptor 2 ligands on mRNA expression of chemokine form human peripheral blood mononuclear cells from patients with atopic dermatitis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800016343
Enrollment
Unknown
Registered
2018-05-25
Start date
2014-01-01
Completion date
Unknown
Last updated
2018-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic Dermatitis

Interventions

Atopic dermatitis patients and health controls:Separated PBMCs form peripheral blood and stimulated with TLR2 ligands

Sponsors

Shenzhen University Health Science Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: All patients were suffering from AD according to the criteria of Hanifin and Rajka, ranging from 20 to 45 years old, with moderate to severe disease activity.

Exclusion criteria

Exclusion criteria: The exclusion criteria included having such diseases in the last 6 months: 1. Hematological diseases; 2. Autoimmune diseases such as systemic lupus erythematosus; 3. Infectious diseases; 4. Application of drug which could affect the number and function of PBMCs, such as chlorpropamide.

Design outcomes

Primary

MeasureTime frame
The mRNA expression of chemokines CCL5/CCL8/CCL13/CCL18/CCL22;—

Countries

China

Contacts

Public ContactDongxu Lin

Shenzhen University

751304998@qq.com+86 13760495383

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026