nasopharyngeal carcinoma
Conditions
Interventions
2:TPF
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Histologically proven WHO types II-III nasopharyngeal carcinoma; 2. Stage III-IVa(except T3-4N0)(8th AJCC); 3. Initial treatment of untreated tumor treatment; 4. No history of secondary malignancy; 5. Male and femle age 18-65 years; 6. Adequate liver function: TBil=ULN; ALT and AST =2 ULN; ALP=5ULN; 7. Adequate renal function: creatinine clearance=80 mL/min; 8. Adequate bone marrow (leukocyte count =4.0×10^9/L, absolute neutrophil count =2.0×10^9/L, platelets =100×10^9/L and HB=9 g/dL); 9. No serious heart and lung dysfunction; 10. PS score = 2; 11. Patients are required to provide written informed consent before undergoing chemoradiotherapy.
Exclusion criteria
Exclusion criteria: 1. Patients with history of previous radiotherapy, chemotherapy and surgery; 2. Evidence of distant metastasis; 3. pregnancy or lactation; 4. Patients could not provide written informed consent before undergoing chemoradiotherapy; 5. Patients with poor compliance due to mental illness or poor social condition; 6. Participated in another clinical trials of any research drug; 7. Severe uncontrolled infection; 8. Major organ dysfunction, such as decompensated cardiopulmonary, kidney, liver failure, cannot tolerate surgical treatment; 9. laboratory examination: TBil=ULN; ALT and or AST =2 ULN;ALP=2.5ULN; 10. Influence on the distribution of drug delivery, metabolism and excretionsuch as mental disorder ,central nervous system abnormality, chronic diarrhea, pleural effusion; 11. Long-term use of immunosuppressive agents after organ transplantation; 12. History of other malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FFS; | — |
Countries
China
Contacts
Public ContactYong Chen
Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed