healthy person
Conditions
Interventions
group 2:Administration: single intravenous injection
administration time: 60 s. Dosage: 2mg/kg.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Half males and half females; 2) Aged between 18~45 years, the weight is not less than 50kg; BMI 19 to 24; 3) Health, no heart, lung, liver, kidney, kidney, digestive tract, nervous system disease and metabolic abnormalities and physical examination (such as electrocardiogram, blood pressure, heart rate, liver function, kidney function, lung function, blood routine etc.) should not be abnormal; 4) The subjects voluntarily signed the informed consent form of the trial.
Exclusion criteria
Exclusion criteria: 1) People who have drug allergy history, allergic disease, allergic constitution; who have allergy history of narcotic drugs or drugs whos structure be similar to trial drugwho are suspected hereditary history of malignant hyperthermia; who are allergic to eggs, soybeans and their products; who have contraindications of study related drugs; 2) Pregnant, lactating women, or those who have pregnancy plans within 1 months (including male subjects); 3) Systolic pressure140 mmHg; Heart rate120 bpm; Postural hypotension subjects; 4) According to the Fridericia formula, the QT/QTc interval was significantly prolonged (male=470 ms, female =480 ms); 5) People with known or expected difficulty airway; 6) Cognitive dysfunction; 7) Coagulation disorders; 8) People who take any other drugs within two weeks before the beginning of the trial,;smoking, drinking and caffeinated beverages during the test period; 9) People who are suspected or confirmed history of alcohol or substance abuse; 10) People who participated in the drug trial (including the trial drug) within 3 months before the trialor who were repeatedly enrolled in this trial; 11) A sponsor or researcher who directly participates in the trial,or their family members; 12) People who are refused by researchers with any reason.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| eyelash reflexes;recovery time;laboratory inspection;Temperature;Pain induced by injection;Other adverse events; | — |
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters;BIS;MOAA/S;??????;circulatory system;heart rate;respiratory system;liver function;renal function; | — |
Countries
China
Contacts
Public ContactZhaomeng Wu
West China Hospital, Sichuan University
Outcome results
None listed