Esophageal cancer
Conditions
Interventions
test group:Cisplatin + raltitrexet combined with intensity modulated conformal radiation therapy
control group:Cisplatin+5-FU Combined with Intensity Conformal Radiation Therapy
Sponsors
The first hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Histopathologically confirmed esophageal squamous cell carcinoma (including high grade squamous intraepithelial neoplasia), clinical stage II-III; 2. Aged 18-70 years old, male or female; 3. There are measurable lesions (RECIST version 1.1); 4. ECOG physical status is 0-1, and the expected survival time is = 6 months; 5. At least fluid diet; 6. Laboratory inspections meet the following requirements: WBC = 4.0×10^9/L, neutrophil count = 2.0×10^9/L, PLT = 100×10^9/L, HB = 100g/L (without blood transfusion); total bilirubin, ALT, AST = 1.5 times the upper limit of normal; serum creatinine = upper limit of normal value (creatinine clearance = 65mL/min); normal ECG; 7. Voluntarily sign a treatment consent form.
Exclusion criteria
Exclusion criteria: 1. Cannot complete the designated pretreatment assessor; 2. The biopsy results are nonsquamous or no biopsy results; 3. Chemotherapy and chest radiotherapy before the start of the trial; 4. The primary disease becomes multifocal esophageal cancer; 5. Fiberoptic bronchoscopy or upper gastrointestinal angiography confirmed that there were tracheoesophageal fistulas and esophageal perforation, and active esophageal hemorrhage; 6. known to have an allergic reaction to any treatment 7. Pregnancy (confirmed by urine/blood examination), breast-feeding women or women who have fertility but have not used contraceptive measures; 8. history of malignancy in other sites; 9. with uncontrolled diabetes, high blood pressure, and severe cardiovascular or pulmonary disease; 10. Attending or participating in other clinical trials within the first four weeks of enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine examination;Liver and kidney function;Heart and lung function;Chest-enhanced CT;Upper and lower cervical collarbone ultrasound scan; | — |
Countries
China
Contacts
Public ContactGuang Li
The first hospital of China Medical University
Outcome results
None listed